Joe N Kornegay Selected Research

Muscular Dystrophies (Muscular Dystrophy)

1/2021	Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength.
1/2021	Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
1/2020	Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy.
10/2019	Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models.
1/2019	Texture as an imaging biomarker for disease severity in golden retriever muscular dystrophy.
10/2018	Glucose Metabolism as a Pre-clinical Biomarker for the Golden Retriever Model of Duchenne Muscular Dystrophy.
3/2017	Mechanism of Deletion Removing All Dystrophin Exons in a Canine Model for DMD Implicates Concerted Evolution of X Chromosome Pseudogenes.
1/2017	Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo.
1/2017	Changes in Muscle Metabolism are Associated with Phenotypic Variability in Golden Retriever Muscular Dystrophy.
1/2017	Whole genome sequencing reveals a 7 base-pair deletion in DMD exon 42 in a dog with muscular dystrophy.

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Joe N Kornegay Research Topics

Disease

37	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 12/2021 - 12/2004
30	Muscular Dystrophies (Muscular Dystrophy) 01/2021 - 12/2004
11	Disease Progression 10/2018 - 01/2011
5	Fibrosis (Cirrhosis) 01/2021 - 04/2010
4	Hypertrophy 01/2016 - 12/2004
3	Necrosis 01/2021 - 02/2014
3	Contracture 01/2017 - 02/2012
2	Inflammation (Inflammations) 01/2021 - 09/2015
2	Cardiomyopathies (Cardiomyopathy) 01/2019 - 04/2010
2	Muscular Atrophy (Muscle Atrophy) 01/2017 - 01/2017
2	Fetal Alcohol Spectrum Disorders 01/2016 - 11/2015
2	Atrophy 01/2016 - 01/2011
1	Animal Muscular Dystrophy 10/2019
1	Muscle Weakness 01/2018
1	Deglutition Disorders (Dysphagia) 01/2018
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2018
1	Myocardial Infarction 01/2016
1	Trismus (Lockjaw) 01/2011
1	Growth Disorders 01/2011
1	Heart Diseases (Heart Disease) 04/2010
1	Ventricular Remodeling 04/2010
1	Heart Failure 04/2010
1	Muscular Diseases (Myopathy) 10/2006
1	Parvoviridae Infections (Parvovirus Infection) 07/2003
1	Hydranencephaly 07/2003

Drug/Important Bio-Agent (IBA)

32	DystrophinIBA 12/2021 - 12/2004
17	Proteins (Proteins, Gene)FDA Link 12/2021 - 04/2010
10	Biomarkers (Surrogate Marker)IBA 01/2020 - 02/2012
4	MyostatinIBA 01/2016 - 12/2011
2	UtrophinIBA 01/2021 - 10/2019
2	Transcription Activator-Like Effector NucleasesIBA 01/2020 - 01/2020
2	EnzymesIBA 10/2018 - 01/2017
2	Pharmaceutical PreparationsIBA 01/2018 - 09/2013
2	OsteopontinIBA 12/2017 - 01/2014
2	MicroRNAs (MicroRNA)IBA 09/2015 - 11/2013
2	Messenger RNA (mRNA)IBA 11/2013 - 10/2011
2	Prednisone (Sone)FDA LinkGeneric 09/2013 - 12/2004
2	UbiquitinIBA 01/2013 - 10/2011
2	CalpainIBA 01/2013 - 10/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2013 - 10/2011
1	Codon (Codons)IBA 01/2020
1	GadoliniumIBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 10/2018
1	Glucose (Dextrose)FDA LinkGeneric 10/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	NucleotidesIBA 01/2018
1	A 7 (A-7)IBA 01/2017
1	Proline (L-Proline)FDA Link 01/2017
1	Arginine (L-Arginine)FDA Link 01/2017
1	Oleic Acid (Oleate)IBA 01/2017
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2016
1	Choline (Choline Chloride)IBA 01/2016
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2014
1	CarbohydratesIBA 01/2014
1	N-glycolylneuraminic acidIBA 01/2014
1	myotrophinIBA 11/2013
1	Dystroglycans (Dystroglycan)IBA 11/2013
1	SpectrinIBA 11/2013
1	Therapeutic UsesIBA 09/2013
1	IntegrinsIBA 09/2013
1	U7 small nuclear RNA (U7 snRNA)IBA 03/2012
1	Small Nuclear RNA (snRNA)IBA 03/2012
1	Creatine Kinase (Creatine Phosphokinase)IBA 12/2011
1	Peptides (Polypeptides)IBA 05/2011
1	calpain inhibitorsIBA 01/2011
1	leupeptinIBA 01/2011
1	Troponin IIBA 04/2010
1	Poloxamer (Poloxamer 407)IBA 04/2010
1	Natriuretic PeptidesIBA 04/2010
1	Actins (F Actin)IBA 07/2007
1	Myosins (Myosin)IBA 12/2004
1	GlucocorticoidsIBA 12/2004
1	DNA (Deoxyribonucleic Acid)IBA 07/2003
1	ParaffinIBA 07/2003

Therapy/Procedure

7	Therapeutics 05/2019 - 04/2010
1	Cell Transplantation 12/2004
1	Hematopoietic Stem Cell Transplantation 12/2004